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Cake day: June 6th, 2023

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  • The immediately obvious way to make such a disease is to make it an actual disease using the affliction rules. This however would get easier to deal with as your characters level up, since the DC will stay constant but the PCs saves will go up. Another way to go about it would be to have a lost of conditions, which accumulate for each day/week. So on the first day/week you gain Clumsy 1, then also Enfeebled 1, then also Clumsy 2 and so forth. This will very quickly become VERY punishing though, unless you carefully pick conditions that don’t affect your PCs very much. The entire list of conditions can be found here. I would probably use Fatigued and Flat-footed for the first few levels and then the ones listed under Lowered abilities after that, maybe even throwing in a Doomed or two along the way. But as I said, this can very quickly become VERY punishing.


  • I would recommend starting over at Lvl 1, because characters get quite a lot of options over the levels, so starting with only the Lvl 1 options can simplify things quite a bit. Though I know that some people have done a “You are depowered for some reason” or “You are dreaming of a time when you weren’t as strong” period to somewhat quickly level up from one to where you were. If you do this, be aware that characters will end up differently than your 5e versions, and that pf2e expected certain magical items at certain levels, such as Potency and Striking runes for martials and Wands and Staves for Casters.